The Faculty of Science and the Division of Drug Discovery and Safety at Leiden University is looking for a Postdoc – iPSC technology to discover targeted therapy for Nrf2 antioxidant response modulation.
Cellular stress response pathways are activated in various diseases, including acute ischemia-reperfusion injury of the liver and kidney, or during neurodegeneration in Parkinson’s and Alzheimer’s disease. These stress response pathways involve oxidative stress, unfolded protein response, DNA damage, and inflammatory signaling. Typically, these responses drive repair processes in cells and prevent ultimate cell death. Likewise, pharmacological modulation of these stress responses can enhance cellular adaptation and repair programs in various disease settings. Here they aim to establish a platform for drug discovery for therapeutic modulation of stress response pathways, with a focus on the Nrf2 antioxidant stress response. The postdoc will establish a panel of iPSC fluorescent reporter systems for critical Nrf2 target genes.
Duration: 12 months
Salary
- Salary range from € 2.846 to € 4.490 gross per month
- Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %),
- Training and career development and sabbatical leave.
Job Requirements
The following are requirements for the Position – iPSC Technology to Discover Targeted Therapy for Nrf2 Antioxidant Response Modulation;
- PhD in Biomedical Sciences, Biology, Toxicology, (Bio)-pharmaceutical Sciences,
- enthusiastic and ambitious
- independent thinker
- expertise in (human) stem cell culture, molecular and cell biology, microscopy, cell
- signaling
- excellent writing skills
- interest in bioinformatics
- team player
Application Process
Interested applicants are to send an email to Prof. Bob van de Water (b.water@lacdr.leidenuniv.nl), Dr. Sylvia Le Dévédec (s.e.ledevedec@lacdr.leidenuniv.nl), and Marjolijn Lugthart (m.j.l.lugthart@lacdr.leidenuniv.nl). Also, ensure to upload the following additional documents quoting the vacancy number:
- motivation letter
- Curriculum Vitae
- preferably 2 reference letters
To apply, click here
Application Deadline: June 13, 2022.
For more information on Position – iPSC Technology to Discover Targeted Therapy for Nrf2 Antioxidant Response Modulation, visit the official site.
